Platelets from patients with myeloproliferative neoplasms have increased numbers of mitochondria that are hypersensitive to depolarization by thrombin
Abstract Thrombosis is one of the cardinal manifestations of myeloproliferative neoplasms (MPN).The mechanisms leading to a prothrombotic state in MPN Hoods are complex and remain poorly understood.Platelet mitochondria play a role in platelet activation, but their number and function have not been extensively explored in MPN to date.We observed an